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KMID : 0359720210390030214
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Journal of the Korean Neurological Association
2021 Volume.39 No. 3 p.214 ~ p.218
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Longitudinal Observation of Early-Onset Alzheimer’s Disease Dementia with Positive CSF Biomarkers/Negative Amyloid-β Positron-Emission Tomography
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Kim Min-Hye
Lee Joon-Ho
Kim Hong-Nam
Shin In-Ja
Lee Keun
Kim Yoon-Seob
Lee Sun-Min
Park Sun-Ah
Moon So-Young
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Abstract
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We report a 61-year-old woman with clinical course for Alzheimer’s disease (AD) dementia and discordant amyloid-β positron-emission tomography (PET) and cerebrospinal fluid biomarkers. Brain magnetic resonance imaging revealed remarkable atrophy in the hippocampus. However, repeated delayed 18F-flutemetamol brain amyloid PET images with 1 year-interval revealed no amyloid deposition, whereas her CSF revealed low Aβ42, high total tau and p-tau181. This discordant amyloid-β PET and CSF biomarkers in this early-onset AD dementia might be associated with her low resilience or mixed pathology.
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KEYWORD
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Amyloid-β, Positron-emission tomography, CSF
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